Both Liverpool and Manchester City will face 15-time winners Real Madrid in the league phase of the Champions League, while Tottenham and Newcastle must both play holders Paris St-Germain.
The 36-team league – introduced last season – will see six Premier League teams in action for the first time, but they can not face each other until the knockout stages.
As well as coming up against Trent Alexander-Arnold and Real at Anfield, six-time winners Liverpool face Atletico Madrid and beaten finalists Inter Milan in their eight games, with Pep Guardiola’s City taking on Napoli and Borussia Dortmund.
Chelsea face giants Barcelona and Bayern Munich while Arsenal also play Harry Kane’s Bayern and Inter.
Newcastle’s return to the competition includes a trip to St James’ Park for Barcelona, while Tottenham – who qualified by winning the Europa League – play Dortmund and Monaco.
The first matches will be played on Tuesday, 16 September and the last round of league games taking place on 28 January 2026, with exact scheduling to follow in the coming days.
This season’s final will be held in Budapest.
When are the matchdays?
Matchday 1: 16–18 September 2025
Matchday 2: 30 September–1 October 2025
Matchday 3: 21/22 October 2025
Matchday 4: 4/5 November 2025
Matchday 5: 25/26 November 2025
Matchday 6: 9/10 December 2025
Matchday 7: 20/21 January 2026
Matchday 8: 28 January 2026
Who is in the competition?
England: Liverpool, Arsenal, Manchester City, Chelsea, Tottenham Hotspur, Newcastle
Azerbaijan: Qarabag
Belgium: Union Saint-Gilloise, Club Brugge
Cyprus: Pafos
Czechia: Slavia Prague
Denmark: FC Copenhagen
France: Paris Saint-Germain, Marseille, Monaco
Germany: Bayern Munich, Bayer Leverkusen, Eintracht Frankfurt, Borussia Dortmund
Greece: Olympiacos
Italy: Napoli, Inter, Atalanta, Juventus
Kazakhstan: Kairat Almaty
Netherlands: PSV, Ajax
Norway: Bodo/Glimt
Portugal: Sporting CP, Benfica
Spain: Barcelona, Real Madrid, Atletico Madrid, Athletic Club, Villarreal
Turkey: Galatasaray
