A head-on train collision at Wassa Manso in the Western region has killed many passengers on board.
The incident is believed to have happened on the Tarkwa-Kojokrom rail route with a number of casualties yet to be accounted for.
Photos from myjoyonline show the noses of both trains mangled with the rail lines disjointed.
Meanwhile, police and fire service crew are at the scene to advance forensic investigation.
According to the Ghana police service, this is the first time that a train wreck of this fatal magnitude has been recorded in the country and in the Western Region.
It comes as rail transport remains 1 percent of transport operations in Ghana as it heavily centers on the transport of raw materials.